Colorectal cancer and the KIR genes in the human genome: A meta-analysis
Identifieur interne : 001280 ( Main/Exploration ); précédent : 001279; suivant : 001281Colorectal cancer and the KIR genes in the human genome: A meta-analysis
Auteurs : Koroush Ghanadi [Iran] ; Bahareh Shayanrad [Iran] ; Seyyed Amir Yasin Ahmadi [Iran] ; Farhad Shahsavar [Iran] ; Hossein Eliasy [Iran]Source :
- Genomics Data [ 2213-5960 ] ; 2016.
Abstract
Colorectal cancer is one of the most common types of inflammation-based cancers and is occurred due to growth and spread of cancer cells in colon and/or rectum. Previously genetic association of cell cycle genes, both proto-oncogenes and the tumor suppressors has been proved. But there were few studies about association of immune related genes such as
Url:
DOI: 10.1016/j.gdata.2016.10.010
PubMed: 27843767
PubMed Central: 5099266
Affiliations:
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Sciences, Khorramabad</wicri:regionArea><wicri:noRegion>Khorramabad</wicri:noRegion></affiliation></author><author><name sortKey="Shahsavar, Farhad" sort="Shahsavar, Farhad" uniqKey="Shahsavar F" first="Farhad" last="Shahsavar">Farhad Shahsavar</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Immunology, Lorestan University of Medical Sciences, Khorramabad</wicri:regionArea><wicri:noRegion>Khorramabad</wicri:noRegion></affiliation></author><author><name sortKey="Eliasy, Hossein" sort="Eliasy, Hossein" uniqKey="Eliasy H" first="Hossein" last="Eliasy">Hossein Eliasy</name><affiliation wicri:level="1"><nlm:aff id="af0020">Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Research Office for the 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sort="Shayanrad, Bahareh" uniqKey="Shayanrad B" first="Bahareh" last="Shayanrad">Bahareh Shayanrad</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Immunology, Lorestan University of Medical Sciences, Khorramabad</wicri:regionArea><wicri:noRegion>Khorramabad</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0015">Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Student Research Committee, Lorestan University of Medical Sciences, Khorramabad</wicri:regionArea><wicri:noRegion>Khorramabad</wicri:noRegion></affiliation></author><author><name sortKey="Ahmadi, Seyyed Amir Yasin" sort="Ahmadi, Seyyed Amir Yasin" uniqKey="Ahmadi S" first="Seyyed Amir Yasin" last="Ahmadi">Seyyed Amir Yasin Ahmadi</name><affiliation wicri:level="1"><nlm:aff id="af0015">Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Student Research Committee, Lorestan University of Medical Sciences, Khorramabad</wicri:regionArea><wicri:noRegion>Khorramabad</wicri:noRegion></affiliation></author><author><name sortKey="Shahsavar, Farhad" sort="Shahsavar, Farhad" uniqKey="Shahsavar F" first="Farhad" last="Shahsavar">Farhad Shahsavar</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Immunology, Lorestan University of Medical Sciences, Khorramabad</wicri:regionArea><wicri:noRegion>Khorramabad</wicri:noRegion></affiliation></author><author><name sortKey="Eliasy, Hossein" sort="Eliasy, Hossein" uniqKey="Eliasy H" first="Hossein" last="Eliasy">Hossein Eliasy</name><affiliation wicri:level="1"><nlm:aff id="af0020">Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad</wicri:regionArea><wicri:noRegion>Khorramabad</wicri:noRegion></affiliation></author></analytic><series><title level="j">Genomics Data</title><idno type="eISSN">2213-5960</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Colorectal cancer is one of the most common types of inflammation-based cancers and is occurred due to growth and spread of cancer cells in colon and/or rectum. Previously genetic association of cell cycle genes, both proto-oncogenes and the tumor suppressors has been proved. But there were few studies about association of immune related genes such as <italic>killer-cell immunoglobulin-like receptors (KIRs)</italic>. Thus we intend to perform a meta-analysis to find the association of different genes of <italic>KIR</italic> and susceptibility to be affected by colorectal cancer. The overall population of the four studies investigated in our meta-analysis was 953 individuals (470 individuals with colorectal cancer and 483 individuals in control groups). After the analyses, we concluded that colorectal cancer is affected by <italic>KIR2DS5</italic> and also there were no protecting gene. This result shows the inflammatory basis of this cancer. In other words, in contrast to leukemia and blood cancers, colorectal cancers seem to be affected by hyper activity of natural killer-cells (NKs). 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Arafah</name></author><author><name sortKey="Al Obeed, O" uniqKey="Al Obeed O">O. Al Obeed</name></author><author><name sortKey="Christmas, S" uniqKey="Christmas S">S. Christmas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shayanrad, B" uniqKey="Shayanrad B">B. Shayanrad</name></author><author><name sortKey="Ahmadi, S A Y" uniqKey="Ahmadi S">S.A.Y. Ahmadi</name></author><author><name sortKey="Shahsavar, F" uniqKey="Shahsavar F">F. Shahsavar</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Ghanadi, Koroush" sort="Ghanadi, Koroush" uniqKey="Ghanadi K" first="Koroush" last="Ghanadi">Koroush Ghanadi</name></noRegion><name sortKey="Ahmadi, Seyyed Amir Yasin" sort="Ahmadi, Seyyed Amir Yasin" uniqKey="Ahmadi S" first="Seyyed Amir Yasin" last="Ahmadi">Seyyed Amir Yasin Ahmadi</name><name sortKey="Eliasy, Hossein" sort="Eliasy, Hossein" uniqKey="Eliasy H" first="Hossein" last="Eliasy">Hossein Eliasy</name><name sortKey="Shahsavar, Farhad" sort="Shahsavar, Farhad" uniqKey="Shahsavar F" first="Farhad" last="Shahsavar">Farhad Shahsavar</name><name sortKey="Shayanrad, Bahareh" sort="Shayanrad, Bahareh" uniqKey="Shayanrad B" first="Bahareh" last="Shayanrad">Bahareh Shayanrad</name><name sortKey="Shayanrad, Bahareh" sort="Shayanrad, Bahareh" uniqKey="Shayanrad B" first="Bahareh" last="Shayanrad">Bahareh Shayanrad</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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